If you remove a spy, the application that has installed it may notice this and refuse to work any longer. Spybot-S&D is able to replace a few spies with harmless dummies; but where that is not possible, I recommend either to search for a good alternative that comes without spy- or adware, or using the recovery option in Spybot-S&D to restore the spy. In the later case, you can do it step by step, until you found the files that are absolutely necessary for the spy, and at least keep some files from your system, like the data saved about you.